Strategy of implementing aerobic exercise as a pleiotropic effect in cancer patients with a history of administration cardiotoxic agents: a systematic review
Main Article Content
Keywords
Cardiomyopathy, Aerobic Exercise, Cardio-protection, Cardiotoxic
Abstract
The development of health science, with the discovery of a type of treatment to reduce mortality due to cancer, namely using chemotherapy agents such as anthracycline and trastuzumab. From the number of studies that have been done, the types of drugs such as anthracycline and trastuzumab have a cardiotoxic effect which is often associated with decreased heart-lung function and the incidence of cardiomyopathy. Exercise is reported to have a pleiotropic effect. Therefore, this study aims to synthesize evidence from the application of pleiotropic exercise in cancer patients undergoing chemotherapy with cardiotoxic agents. The search was performed according to the recommended reporting items for systematic review and meta-analyses (PRISMA). Obtained an accumulation of 2397 articles from PubMed and Google Scholar (2016-2020), which were assisted by the PICO search engine. The article was reviewed by the author within sorting using inclusion and exclusion criteria and obtained 28 articles accordingly. Aerobic exercise has pleiotropic effects by stimulating antioxidants and reducing reactive oxygen species (ROS) levels, reducing pro-apoptosis molecular signaling, stimulating myofilament, facilitating concentric cardia hypertrophy remodeling, and changing cardiac metabolism via adenosine monophosphate (amp) with kinase-mediated. Pretreatment aerobic exercise with minimal supervised 30-min exercise sessions 3 times/week for ≥12 weeks effectively reduce the risk of chemotherapy-induced cardiomyopathy (CRC). Aerobic exercise has a significant pleiotropic effect in patients undergoing chemotherapy with cardiotoxic agents.
References
2. Riko, J. (2018). Karakteristik Pasien Karsinoma Nasofaring Di Poliklinik THT-KL RSUP DR. M. Djamil Padang Tahun 2014-2015 (Doctoral dissertation, Universitas Andalas).
3. Friedel, M., Brichard, B., Fonteyne, C., Renard, M., Misson, J. P., Vandecruys, E., ... & Ruysseveldt, I. (2018). Building Bridges, Paediatric Palliative Care in Belgium: A secondary data analysis of annual paediatric liaison team reports from 2010 to 2014. BMC palliative care, 17(1), 77.
4. Schmitz K, Courneya K, Matthews C, Demark-Wahnefried W, Galvao D, Pinto B, Irwin M, Wolin K, Segal R, Lucia A, Schneider C, von Gruenigen V, Schwartz A. American College of Sports Medicine. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sport Exerc 42: 1409 –1426, 2010. doi:10. 1249/MSS.0b013e3181e0c112.
5. Westphal JG, Schulze PC. Exercise training in cancer related cardiomyopathy. J Thorac Dis 2018;10(Suppl 35):S4391-S4399. doi: 10.21037/jtd.2018.12.53
6. Chen, J. J., Wu, P. T., Middlekauff, H. R., & Nguyen, K. L. (2017). Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions. American Journal of Physiology-Heart and Circulatory Physiology, 312(2), H213-H222.)
7. Vejpongsa P, Yeh ET. Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities. J Am Coll Cardiol 64: 938 –945, 2014. doi:10.1016/j.jacc.2014.06.1167.
8. Scott JM, Khakoo A, Mackey JR, Haykowsky MJ, Douglas PS, JonesLW. Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms.Circulation 124: 642–650, 2011. doi:10.1161/CIRCULATIONAHA.111.021774.
9. Smuder AJ, Kavazis AN, Min K, Powers SK. Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals. J Appl Physiol (1985) 115: 176 –185, 2013. doi:10.1152/japplphysiol.00924.2012.
10. Onitilo, Adedayo A., Jessica M. Engel, and Rachel V. Stankowski. "Cardiovascular toxicity associated with adjuvant trastuzumab therapy: prevalence, patient characteristics, and risk factors." Therapeutic advances in drug safety 5.4 (2014): 154-166.
11. Vieira, Melissa de Carvalho Souza, et al. "Effect of physical exercise on the cardiorespiratory fitness of men—A systematic review and meta-analysis." Maturitas 115 (2018): 23-30.
12. Lee, K., Kang, I., Mack, W. J., Mortimer, J., Sattler, F., Salem, G., & Dieli-Conwright, C. M. (2019). Feasibility of high intensity interval training in patients with breast Cancer undergoing anthracycline chemotherapy: a randomized pilot trial. BMC cancer, 19(1), 653.
13. Mowafy, Z. M. E., Zoheiry, I. M. I., Elmonem, M. G. A., & Katter, D. (2016). Efficacy of aerobic training on maximal oxygen consumption and total leukocytes count after chemotherapy in breast cancer patients. International Journal of PharmTech Research, 9, 34-40.
14. Adams, S. C., DeLorey, D. S., Davenport, M. H., Stickland, M. K., Fairey, A. S., North, S., ... & Courneya, K. S. (2017). Effects of high‐intensity aerobic interval training on cardiovascular disease risk in testicular cancer survivors: A phase 2 randomized controlled trial. Cancer, 123(20), 4057-4065.
15. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. (2015). Pedoman Tatalaksana Gagal Jantung. PERKI. Avaliable at : http://www.inaheart.org/upload/image/Pedoman_TataLaksana_Gagal_Jantung_2015.pdf (Accessed 12/9/2020).
16. Rocha, B. M. L., et al. "Risk stratification in hf with mid-range LVEF: the role of cardiopulmonary exercise testing." European Heart Journal 41.Supplement_2 (2020): ehaa946-0940.
17. Jacquinot, Quentin, et al. "A phase 2 randomized trial to evaluate the impact of a supervised exercise program on cardiotoxicity at 3 months in patients with HER2 overexpressing breast cancer undergoing adjuvant treatment by trastuzumab: design of the CARDAPAC study." BMC cancer 17.1 (2017): 425.
18. Costello, Benedict T., et al. "Exercise Attenuates Cardiotoxicity of Anthracycline Chemotherapy Measured by Global Longitudinal Strain." JACC: CardioOncology 1.2 (2019): 298-301.
19. Kirkham, A. A., Virani, S. A., Bland, K. A., McKenzie, D. C., Gelmon, K. A., Warburton, D. E., & Campbell, K. L. (2020). Exercise training affects hemodynamics not cardiac function during anthracycline-based chemotherapy. Breast Cancer Research and Treatment, 184(1), 75-85.
20. Kamelia, Telly, et al. "Perubahan Konsentrasi Amino Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) dan Fraksi Ejeksi Ventrikel Kiri pada Pasien Kemoterapi Doksorubisin." Jurnal Penyakit Dalam Indonesia 4.2 (2017): 78-83.
21. Kirkham, A. A., Eves, N. D., Shave, R. E., Bland, K. A., Bovard, J., Gelmon, K. A., ... & Campbell, K. L. (2018). The effect of an aerobic exercise bout 24 h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT. Breast cancer research and treatment, 167(3), 719-729.
22. Kusnandang, Agus. "Framingham Score dan Jakarta Cardiovascular Score untuk Menentukan Kejadian Cardiovaskuler Event Pekerja Rumah Sakit Pertamina Cirebon." Tunas Medika Jurnal Kedokteran & Kesehatan 5.3 (2019).
23. Law, W., et al. "The Framingham risk score underestimates the risk of cardiovascular events in the HER2-positive breast cancer population." Current Oncology 24.5 (2017): e348.
24. Lee, K., Tripathy, D., Demark-Wahnefried, W., Courneya, K. S., Sami, N., Bernstein, L., ... & Dieli-Conwright, C. M. (2019). Effect of aerobic and resistance exercise intervention on cardiovascular disease risk in women with early-stage breast cancer: a randomized clinical trial. JAMA oncology, 5(5), 710-714.
25. Tsai E, Mouhaya E, Lenihan D, Song J, Durand J-B, Fadol A, et al. Feasibility and Outcomes of an Exercise Intervention for Chemotherapy-Induced Heart Failure. J Cardiopulm Rehabil Prev. 2019;39(3):199–203.
26. Ma, Z. (2018). Effect of anthracycline combined with aerobic exercise on the treatment of breast cancer. Pakistan journal of pharmaceutical sciences, 31.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Anak Agung Gede Kesuma Yudha, Faculty of Medicine and Health Science, Universitas Warmadewa, Bali, Indonesia
Faculty of Medicine and Health Science, Universitas Warmadewa, Bali, Indonesia